Weight-Loss Projection & Dosing Calculator
Last updated July 2, 2026 · Medically reviewed by David Chen, MD, PhD
Pick a compound and enter your stats to project expected weight loss over time from clinical-trial data, and to see the week-by-week titration schedule used to escalate the dose safely. Modern Bio provides this for laboratory and research use only — it is not medical advice.
Weight Projection
Projected weight loss from clinical-trial data. Hover or hold on the graph to see the dose at each week.
| Weeks | Phase | Dose |
|---|---|---|
| 1 – 4 | Escalation | 2 mg |
| 5 – 8 | Escalation | 4 mg |
| 9 – 12 | Escalation | 8 mg |
| 13 – 38 | Plateau | 9 mg |
| 39 – 46 | Maintenance | 4 mg |
How to dose GLP-1 peptides
Every compound in this class follows the same principle: start low and go slow. Beginning at a small dose and increasing every four weeks lets the gut adapt, which is what keeps nausea and other gastrointestinal effects manageable. The schedule above shows the standard escalation, plateau, and maintenance doses for the selected compound.
Before any of this matters, the peptide has to be measured accurately — which means reconstituting it correctly first. Use the reconstitution calculator to convert your dose in milligrams to units on the syringe, and review side effects and how to manage them.
Frequently asked questions
- How is projected weight loss calculated?
- The projection interpolates published clinical-trial weight-loss curves for the selected compound and dose, scaled to your starting stats. It assumes no diet or activity changes and is for research and educational use only.
- What is a titration schedule?
- GLP-1 peptides are started at a low dose and stepped up every four weeks to let the body adjust and limit gastrointestinal side effects. The schedule table shows the dose for each week through escalation, plateau, and maintenance.
- Which compound loses the most weight?
- In head-to-head trial data, retatrutide (triple agonist) leads, followed by tirzepatide (dual agonist), then semaglutide (single agonist). Switch compounds in the calculator to compare projections.
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